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Enter Drug ID (e.g. "Loxapine" or "DB00408"):

Recognizes DrugBank ID and some common drug names.

Enter Target ID (e.g. "ADRB2" or "BE0000694"):

Recognizes ID from DrugBank, UniProt, GenAtlas.
No of Predictions (1 to 100):
Secondary Interactions:

Data on protein-drug interactions are rapidly increasing and being collected in databases such as DrugBank. The information in these databases usually reflects known/observed interactions, while the lack of data for a given protein-drug pair does not necessarily mean that those protein-drug molecules are not interacting. Indeed, recent studies supported by both computations and experiments indicate that many drugs have side effects (i.e. they target proteins) other than those known/compiled in DrugBank. This latter property may be exploited for designing ‘repurposable’ drugs or polypharmacological treatments. Efficient identification of such potential interactions is an important challenge that is likely to accelerate drug discovery and development efforts. There is a need for efficient identification of such data, and efficient dissemination of results.

BalestraWeb addresses this need by learning a probabilistic latent factor model of drug-target interactions and enabling users to predict the interactions of:

  • any known drug against all targets (by providing only a drug identifier)
  • any target against all known, approved drugs (by providing only a target identifier)
  • any drug-target pair (by providing both a drug and a target identifier)

BalestraWeb is built using GraphLab's collaborative filtering toolkit implementation, DrugBank's drug-target interaction data, NumPy's matrix and vector operation libraries, the Flask web application framework and the Python programming language. The interactive network visualizations are made using the Data-Driven Documents JavaScript library. Cytoscape is used for the static visualization of the entire drug-target interaction network.

Built by: Murat Can Cobanoglu.

Designed by: MC Cobanoglu, ZN Oltvai, DL Taylor, I Bahar.

Supported by:

Citation: MC Cobanoglu, ZN Oltvai, DL Taylor, I Bahar. (2015) Bioinformatics 31, 131-133.

Funding: Support for BalestraWeb development is provided by NIH awards U19 AI068021 and P01 DK096990.

Copyright © 2013-2014, University of Pittsburgh

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